Small Molecule Inhibitors of Acid Sensing Ion Channel‐1
نویسندگان
چکیده
منابع مشابه
Small molecule inhibitors of acid sphingomyelinase.
Despite of the importance of the acid sphingomyelinase for sphingomyelin homeostasis and sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An increasing set of data on the inhibition of acid sphingomyelinase in different disease models using indirect inhibitors has been generated and strongly implies acid sphingomyelinase as an emerging drug target. Very recentl...
متن کاملSmall molecule inhibitors of bacterial quorum sensing and biofilm formation.
Bacteria monitor their local population densities using small molecules (or autoinducers) in a process known as quorum sensing. Here, we report a new and efficient synthetic route to naturally occurring bacterial autoinducers [N-acyl l-homoserine lactones (AHLs)] that is readily amenable to the synthesis of analogues. This route has been applied in the first synthesis of a library of non-native...
متن کاملTargeting Staphylococcus aureus Quorum Sensing with Nonpeptidic Small Molecule Inhibitors
A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (AIP) activated AgrC receptor, by altering the activation efficacy of the cognate AIP-1. They appeared to act as neg...
متن کاملSmall-molecule inhibitors of the pseudaminic acid biosynthetic
19 Helicobacter pylori is motile by means of polar flagella and this motility has been shown to play 20 a critical role in pathogenicity. The major structural flagellin proteins have been shown to be 21 glycosylated with the nonulosonate sugar, pseudaminic acid (Pse). This glycan is unique to 22 microorganisms and the process of flagellin glycosylation is required for H. pylori flagellar 23 ass...
متن کاملSmall molecule inhibitors of ceramidases.
The equilibrium between the pro-apoptotic ceramide and pro-vital sphingosine-1-phosphate is considered to be decisive for cell death or survival. The different ceramidases thus play key roles in cell fate and might offer attractive targets for pharmacological intervention. Although until recently only moderately active inhibitors have been described, first in vivo experiments suggest activity a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.608.11